Classification:
Antiinfection, Antiviral, Antiretroviral agent; Nucleoside Reverse Transcriptase Inhibitor (NRTI)
Prototype: Zidovudine
Pregnancy Caterogy: C
Availability 300 mg tablets; 20mg mL oral solution
Actions:
Abacavir is a synthetic nucleoside analogue with inhibitory activity against HIV. It inhibit the activity of HIV-1 Reverse Transcriptase (RT) both by completing with the natural DNA nucleoside and by incorporation into viral DNA.
Theraputic Effects:
Abacavir prevents the formation of viral DNA replication. Therefore the viral load decreases as measured by an increased CD4 lymphocyte cell count and suppression of HIV RNA, indicated...
